The Role of Proton-Coupled Amino Acid Transporter 2 (SLC36A2) in Cold-Induced Thermogenesis of Mice

Brown adipocytes mainly utilize glucose and fatty acids to produce energy, which play key roles in thermogenesis. Furthermore, brown also other substrates, such as amino acids, for energy expenditure various conditions. Here, we report the new physiological of proton-coupled acid transporters, SLC36A2 SLC36A3, on global metabolism. The relative mRNA expression levels both Slc36a2 Slc36a3 were all highest adipose tissue. We then generated knockout mice investigate their functions Neither loss nor affected body weight composition mice. exhibited increased oxygen consumption during daytime. After cold treatment, inhibition significantly decreased mass tissue compared wildtype mice, while it lowered level Cpt1a. Moreover, serum lipid liver after treatment. On contrary, impaired tolerance up-regulated LDL-cholesterol concentration. Thus, SLC36A3 central different metabolism